Despite the benefits of B/F/S over glass, some pharmaceutical companies refuse to make the switch because of a number of objections.
A customer enlisted Catalent to support their child-resistant blister packaging requirements for a global Phase III study. A flexible design was created with an integrated blister card that could also support larger study requirements of 1.9 million monthly dosing cards. Through customized commercial blistering equipment a solution was provided that would accommodate the customer’s growing demands for clinical supplies.
Understand the strategies which can be employed at the different stages of development when choosing parenteral dosage forms.
This method can be used to identify potential points of weakness in a film or seal during the manufacturing process by simulating circumstances whereby the material may burst during packaging and transport.
MDIs are designed to deliver precise/accurate and reproducible doses of the drug to the lungs or nose. Good performance is crucial as patients rely on their inhaler to deliver the required dose of medication at often crucial times.
The degree of stiffness of a blister pack will affect its effectiveness. Measuring the required force to push-through a blister pack is therefore necessary.
As the industry continues its move toward biologics, innovative solutions and technologies will be needed to ensure a safe and reliable approach to the manufacturing and delivery of these drugs.