Understanding segregation and how it is related to drug development cost is at the heart of solving this issue and is the topic of this article.
How non-destructive headspace analysis information can be critical for QC groups performing stability studies, or for packaging development groups responsible for choosing the optimal packaging.
Rapid non-destructive headspace moisture analysis from LIGHTHOUSE enables fast moisture determination of statistical numbers of lyo samples.
In cases where oxidation of the formulation causes discoloration and eventual degradation of the product, non-destructive headspace analysis tests can give deep insight into the root cause. Since the samples are not destroyed by the headspace analysis, further testing can be done to accurately correlate headspace conditions with other product characteristics.
Adults and children alike often struggle with compliance and acceptance of medication regimens due to the sizes and shape of prescribed tablets. One pharmaceutical manufacturer sought to create a convenient, easy-to-swallow dosage form by taking an alternative approach: three-dimensional printing (3DP). This white paper outlines their approach to creating an FDA validated manufacturing process for rapidly disintegrating dosage forms.
Mixer testing simulation trials are needed to confirm the suitability of a specific mixing strategy. This white paper explores five ways to increase energy efficiency in new and existing mixing processes.
Uniformly dispersing powders into a liquid batch in a practical amount of time is a common problem for F&B manufacturers. This white paper explores five tips for dispersing powders more efficiently.
Used Korsch rotary tablet press, model PH250/25, 25 station, 20 Kn pre compression, 80 Kn main compression, 16 mm max tablet diameter, 18 mm max depth of fill, single side with force feeder, rated up to 180000 tablets/hour, serial# 1.0031.94, built 1994.
used Key International rotary tablet press, model DS3, 10 ton compression, 15 station, keyed upper punch guides, 1 3/16" max tablet diameter, 1 1/16" max depth of fill, rated up to 335 tablets/minute, with feed hopper and feed frame, serial# J-1858.
NJM Bottle Filling Line Composed of NJM 36'' Diameter Inlet Turn Table, Cremer CF-1220 Tablet Counter with HHT, Kaps-All Capper (Cap Feeder), Cap Inspection System, Enercon Super Seal 75, NJM 36'' Diameter Accumulation/ Transfer Turn Table, Kaps-All Retorquer, NJM Model 120 Minicolt Labeler, NJM 36'' Diameter Outlet Turn Table, NJM 29FT Curved Conveyor, NJM 12'' Stainless Steel Motorized Transfer Table, Electrical Power Box, and Donaldson Torit Dust Collector.
Used Fette 1200 rotary tablet press, 24 station, 80 Kn main compression, 80 Kn pre-compression, single sided, 16 mm max tablet diameter, 18 mm max depth of fill, with force feeder with feed hopper, keyed upper punch guides, rated up to 172000 tablets/hour, on board control panel with separate operator HMI interface, 330/510 volt, serial# 09-313, built 2001.
Used Groninger filling line, consisting of model KFVG 4211A Groniger filler, plugger, capper, with (4) piston filling station, bowl feeders with plugs and caps, bottle feed station with accumulation table, serial# 7170, built 2006, Mettler Toledo Hi Speed checkweigher, model Starweight-XSPMWD, Groninger tray loader, model MAG 105, serial# 8106, built 2008, with change parts for 30, 120, 250 and 500 Ml plastic bottles.
HPAPI Drying and Multi-Fill Suite designed as a complete sampling system with a nitrogen glovebox enclosure for processing and drying of HPAPI (High Potency Active Pharmaceutical Ingredients) connected to a laminar flow hood. Designed for product and personnel protection during filling of small sampling containers.
Ropack Pharma Solution’s ample, nimble capacity and validated processes bring quality and reliability to encapsulation.
