FEATURED ARTICLES

• Solving Segregation Effects In Solid-Dosage Form Operations

  Understanding segregation and how it is related to drug development cost is at the heart of solving this issue and is the topic of this article.

• Early Detection Of Powder Flowability Challenges In Formulation Development Of Solid Dosage Forms
• Patient-Centric Drug Design — A Clinical And Academic Perspective
• How To Increase Regulatory Flexibility And Tablet Production Efficiency
• The Key To Continuous Manufacturing

WHITE PAPERS & CASE STUDIES

• Precision Powder In Capsule Micro Dosing Accelerates Drug Product Development

  Advancing active pharmaceutical ingredients (APIs) through the drug product-development lifecycle is fraught with challenges. Development timelines are tight, so it’s crucial to determine early in the process if an API is a viable candidate for clinical testing. A key tool that has emerged to address these combined issues of tight timelines and complex molecules is precision powder micro-dosing in capsules. This paper describes the use of precision micro-dosing to prepare API powder-in-capsule (PIC) dosage forms for oral or pulmonary administration.

• Determination Of Moisture Permeation During Product Shelf Life

  How non-destructive headspace analysis information can be critical for QC groups performing stability studies, or for packaging development groups responsible for choosing the optimal packaging.

• Lyo Chamber Moisture Mapping

  Rapid non-destructive headspace moisture analysis from LIGHTHOUSE enables fast moisture determination of statistical numbers of lyo samples.

• Root Cause Investigation Into A Possible Container Closure Integrity Failure

  In cases where oxidation of the formulation causes discoloration and eventual degradation of the product, non-destructive headspace analysis tests can give deep insight into the root cause. Since the samples are not destroyed by the headspace analysis, further testing can be done to accurately correlate headspace conditions with other product characteristics.

• Redefining Fast Melt For Pharma With 3D Printing

  Adults and children alike often struggle with compliance and acceptance of medication regimens due to the sizes and shape of prescribed tablets. One pharmaceutical manufacturer sought to create a convenient, easy-to-swallow dosage form by taking an alternative approach: three-dimensional printing (3DP). This white paper outlines their approach to creating an FDA validated manufacturing process for rapidly disintegrating dosage forms.

• 5 Steps To Increase Energy-Efficient Mixing

  Mixer testing simulation trials are needed to confirm the suitability of a specific mixing strategy. This white paper explores five ways to increase energy efficiency in new and existing mixing processes.