Understanding segregation and how it is related to drug development cost is at the heart of solving this issue and is the topic of this article.
How non-destructive headspace analysis information can be critical for QC groups performing stability studies, or for packaging development groups responsible for choosing the optimal packaging.
Rapid non-destructive headspace moisture analysis from LIGHTHOUSE enables fast moisture determination of statistical numbers of lyo samples.
In cases where oxidation of the formulation causes discoloration and eventual degradation of the product, non-destructive headspace analysis tests can give deep insight into the root cause. Since the samples are not destroyed by the headspace analysis, further testing can be done to accurately correlate headspace conditions with other product characteristics.
Adults and children alike often struggle with compliance and acceptance of medication regimens due to the sizes and shape of prescribed tablets. One pharmaceutical manufacturer sought to create a convenient, easy-to-swallow dosage form by taking an alternative approach: three-dimensional printing (3DP). This white paper outlines their approach to creating an FDA validated manufacturing process for rapidly disintegrating dosage forms.
Mixer testing simulation trials are needed to confirm the suitability of a specific mixing strategy. This white paper explores five ways to increase energy efficiency in new and existing mixing processes.
Uniformly dispersing powders into a liquid batch in a practical amount of time is a common problem for F&B manufacturers. This white paper explores five tips for dispersing powders more efficiently.
Used BWI Manesty Unipress Diamond rotary table press, 27 station, keyed upper punch guides, 6.5 ton main compression, 1 ton pre compression, B tooled, 16 mm max tablet diameter, 18 mm max depth of fill, single side with force feeder with feed hopper, rated up to 196,200 tablets/hour, serial# UN248JA.
Hata Tablet Press, Model HT-AP55-DU/I.E. Double sided, serial number Nov. 90 - Oct. 1991
Used Fette rotary tablet press, model 3090, 61 station, keyed upper punch guides, 100 KN main compression, 100 KN pre compression, dual sided with force feeders, 16 mm max tablet diameter, 18 mm max depth of fill, rated up to 585,500 tablets/hour, removable turret, stand alone control panel, serial# 290545, built 2008.
Used Manesty Express rotary tablet press, 20 station, 10 ton compression pressure with 1 ton pre compression, 1" max tablet diameter, 13/16" max depth of fill, keyed upper punch guides, single sided with force feeder and feed hopper, rated up to 120,000 tablets/hour throughput, 588 hours on meter, serial# 1399772, rebuilt by Natoli, serial# 10840R.
Used Manesty Express rotary tablet press, 20 station, 10 ton compression pressure with 1 ton pre compression, 1" max tablet diameter, 13/16" max depth of fill, keyed upper punch guides, single sided with force feeder and feed hopper, rated up to 120,000 tablets/hour throughput, 588 hours on meter, serial# 1399772, rebuilt by Natoli, serial# 10840R.
Used Key International single station bench top tablet press, model: SC-2. 1.5 ton compression pressure, approximately .5" max tablet diameter, .5625" max depth of fill, manual operation, serial# JI4786.
AIM™ Pro Plus Control System Makes Tablet Production Easy
The Natoli AIM™ Pro Plus control system is a flexible software and hardware architecture that is standard on Natoli production tablet presses. This industry-leading package can be retrofitted to almost any production tablet press to increase production, improve tablet consistency, and provide an easier-to-manage production environment.
Used MG2 capsule filler, model LABBY, rated up to 3000 capsules/hour, with size 0,1 and 3 change parts, 230 volt, serial# 7621, built 2012.
