FEATURED ARTICLES

• Solving Segregation Effects In Solid-Dosage Form Operations

  Understanding segregation and how it is related to drug development cost is at the heart of solving this issue and is the topic of this article.

• Early Detection Of Powder Flowability Challenges In Formulation Development Of Solid Dosage Forms
• How To Increase Regulatory Flexibility And Tablet Production Efficiency
• The Key To Continuous Manufacturing
• Accurate Bulk Density Measurement Maximizes Solid Dose Production

WHITE PAPERS & CASE STUDIES

• Hot Melt Extrusion: Improving Solubility Of Poorly Soluble Compounds

  As you create your hot-melt extrusion (HME) strategy to manufacture amorphous solid dispersions (ASDs), there are several considerations to ensure your plan is flexible, robust, and comprehensive.

• Precision Powder-In-Capsule Micro-Dosing Accelerates Drug Development

  Precision powder micro-dosing in capsules makes it possible to quickly get formulations to the clinic, saving time, money, and use of limited APIs.

• Determination Of Moisture Permeation During Product Shelf Life

  How non-destructive headspace analysis information can be critical for QC groups performing stability studies, or for packaging development groups responsible for choosing the optimal packaging.

• Lyo Chamber Moisture Mapping

  Rapid non-destructive headspace moisture analysis from LIGHTHOUSE enables fast moisture determination of statistical numbers of lyo samples.

• Root Cause Investigation Into A Possible Container Closure Integrity Failure

  In cases where oxidation of the formulation causes discoloration and eventual degradation of the product, non-destructive headspace analysis tests can give deep insight into the root cause. Since the samples are not destroyed by the headspace analysis, further testing can be done to accurately correlate headspace conditions with other product characteristics.

• Redefining Fast Melt For Pharma With 3D Printing

  Adults and children alike often struggle with compliance and acceptance of medication regimens due to the sizes and shape of prescribed tablets. One pharmaceutical manufacturer sought to create a convenient, easy-to-swallow dosage form by taking an alternative approach: three-dimensional printing (3DP). This white paper outlines their approach to creating an FDA validated manufacturing process for rapidly disintegrating dosage forms.