Formulation Development Applications & Studies

1. Long-Acting GnRH Antagonist For Advanced Prostate Cancer 10/16/2026

   Achieve rapid testosterone suppression for 6+ months with a novel low-volume subcutaneous depot formulation, eliminating the initial surge and offering a new approach for advanced prostate cancer treatment.

2. Why Early Device Decisions Matter: How Immunovant Accelerated Its Program 10/15/2026

   Deferring autoinjector selection can seem to preserve flexibility, yet it often moves constraints downstream. Integrating the device during Phase IIb changed one program's timeline and removed bridging work.

3. Using Human-Centered Engineering To Improve HPLC Solvent Handling 10/15/2026

   Real-world HPLC workflows show how closed-system solvent handling can address contamination, downtime, and waste across laboratory settings.

4. Reducing Cycle Time By 88% Through Strategic Solvent Replacement In Pharmaceutical Development 10/14/2026

   Replacing methylene chloride in a slow, labor-intensive API step led to a single-solvent, one-pot process with a shorter reaction time and improved yield and purity.

5. Improving Stability Through Science-Led OSD Reformulation 10/13/2026

   A marketed multivitamin tablet spanning a 0.03% to 46% w/w range failed early in accelerated stability testing. Mechanism-led reformulation and a switch to direct compression changed the outcome.

6. De-Risking Complex Generic OSD Development 10/13/2026

   Complex generic tablet development requires early alignment of regulatory strategy, QbD formulation, discriminatory dissolution, and reference-scaled bioequivalence.

7. Formulation And Process Challenges For A Needle-Shaped API 9/28/2026

   Managing challenging active pharmaceutical ingredient crystal structures and choosing dry granulation over wet granulation requires strategic processing choices.

8. From Sequence To Scale In Seven Months 9/26/2026

   Accelerate recombinant protein development from sequence to scale while maintaining stable expression, manufacturing efficiency, and critical quality attributes.

9. Characterizing Protein Stability By DSC 9/24/2026

   Discover how differential scanning calorimetry quantifies the thermodynamic forces behind protein folding and stability, providing valuable insight for protein engineering and therapeutic formulation.

10. Life Science Applications Of DSC 9/24/2026

    Learn how Differential Scanning Calorimetry directly measures macromolecular stability, unfolding, and binding interactions, providing valuable thermodynamic insights for protein engineering.