Formulation Development Applications & Studies

  1. Precise Control Of Gas Flows Within The BIOSTAT® B-DCU

    To meet the oxygen demand of cells a stable pO2 control is an essential part of every cultivation. The objective of this application note is to demonstrate the performance of a new generation of mass flow controllers in the BIOSTAT® B-DCU bioreactor system. Several comparative cell cultivations were performed.

  2. Automated Glucose Control

    Ensuring that the cells do not have too much or too little, enables them to grow fast and maximize the product secretion. Within this application is an example method on how to establish glucose feed control is documented and as well as highlighting the key benefits of applying this method to other processes.

  3. Closed And Semi-Automated Processing Of CAR T Cells

    Challenges of T cell immunotherapies include the costly manufacturing process relying on lengthy and complex open workflows with high manual labor requirements that influence product variability. This application note describes the details of a robust CAR T cell manufacturing workflow that can be adapted for cGMP compliance in commercial production of CAR T cells.

  4. S.U.B. Enhancements For High-Density Perfusion Cultures

    This study presents how strategic enhancements to the sparge and agitation systems of Thermo Scientific HyPerforma S.U.B.s have revealed the potential for a three- to four-fold improvement in mixing and mass transfer performance compared to legacy S.U.B. designs.

  5. Improved Bioavailability Of Trio Medicines In 12 Weeks

    Learn how a structured 3-step approach can help overcome the challenge of molecular characterization and a limited budget.

  6. Multifunctional Additives For Better Stability Of Probiotic Formulations

    How SYLOID FP silica products contribute significantly in mitigating/resolving key challenges such as formulation stability over time and their ability to withstand challenging processing conditions.

  7. A Carrier For Liquid Drug Solubilizers In Solid Dosage Form Pharmaceuticals

    The combined adsorption capacity, porosity, particle size, and density of the SYLOID® XDP silicas provide a tool to convert liquid ingredients into free flowing powder.

  8. The Formulation Of Viscous Simethicone Into Chewable Tablets

    Grace’s SYLOID® 244 FP silica is highly porous and an excellent solution for converting viscous Simethicone into compressible free flowing powder to make chewable tablets.

  9. Multifunctional Excipients For The Pharmaceutical Industry

    SYLOID® FP and XDP silicas excipients are micronized synthetic amorphous silica gels of high purity which are widely formulated into many pharmaceutical products.

  10. Moisture Activated Dry Granulation (MADG): An Innovative Way To Make Pharmaceutical Processing Easier

    This moisture activated dry granulation (MADG) technique provides a way to address common problems such as endpoint detection, drying, and milling with an efficient, cost-effective granulating process.