Formulation Development Applications & Studies

1. Characterizing mRNA Using Ion-Pairing Reversed-Phase LC/MS 7/30/2026

   mRNA poly(A) tail analysis depends on targeted digestion, clean LC/MS conditions, and reliable deconvolution. See how RNase 4 digestion and optimized ion-pairing methods support reproducible results.

2. Effect Of Column Chemistry On The Separation Of GLP-1 Peptides 7/29/2026

   Small changes in mobile phase, temperature, and column chemistry can affect the detection of GLP-1 peptide impurities. Learn which conditions improve resolution for challenging peptide analyses.

3. Predicting Food Effects In Oral Drug Delivery Using PBPK Modeling 7/15/2026

   Learn how integrated PBPK and molecular dynamics modeling predicted an ~11% fed-state Cmax increase for fenofibrate, giving formulation teams earlier, mechanistic insight into food-dependent absorption.

4. Compaction Simulation For Tablet Technology Transfer And Scale-Up 7/15/2026

   Compaction simulation de-risked tech transfer for a 40 mg fexuprazan tablet by defining optimal roller compaction and lubrication parameters before scale-up. Access the full case study to see the data.

5. Predicting Softgel Stability And Shelf Life Using Accelerated Modeling 7/15/2026

   Predict ibuprofen softgel shelf life in 21 days instead of years. ASAPprime modeling identified PEG-ester degradants as the limiting factor, estimating 5.5-year and 3.8-year shelf lives before long-term studies concluded.

6. Predicting Drug-Loading Limits In Tablet Formulations 7/15/2026

   Learn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.

7. Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies 7/15/2026

   In silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.

8. Unlocking Robust Separations For Modern Peptide Therapeutics 7/14/2026

   As peptide therapeutics grow more complex, impurity profiling demands greater chromatographic confidence. See how robust reproducibility can support reliable GLP-1 receptor agonist analysis.

9. Developing Non-PEG Stabilizer Lipids For Nucleic Acid Lipid Nanoparticles 7/1/2026

   Non-PEG stabilizer lipids may offer a new path for LNP design. Combining strong colloidal performance with greater chemical flexibility helps address growing concerns around PEG-related immunogenicity.

10. Neoantigen-Based Personalized Cancer Vaccine 7/1/2026

    Personalized cancer vaccines are advancing quickly, but effective delivery remains a major hurdle. Learn how mRNA and lipid nanoparticle design influence targeting, endosomal escape, and repeat dosing.