Formulation Development Applications & Studies
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AAV Full/Empty Capsid Separation Using Mechanistic Modeling
5/1/2023
In this study, we used mechanistic modeling to investigate how AAV-resin interactions are affected when MgCl2 is used as an elution additive.
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Recombinant Protein Purification Optimization With HIC
5/1/2023
A step-by-step high-throughput process development (HTPD) workflow to determine the optimal resin and initial conditions for hydrophobic interaction chromatography (HIC).
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Alkaline Stability Of Fc And VH3 Binding In Protein A Resins
5/1/2023
In this study, we looked at how different antibody binding sites of a protein A ligand are affected by cleaning in place (CIP).
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A Taste Masked And Easily Swallowed Malaria Drug For Elderly Patients
4/20/2023
Dysphagia impacts treatment compliance and disproportionately affects the elderly. Learn how microencapsulation enabled formulation of a water-soluble powder drives patient adherence.
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An Easy-To-Swallow Depression Drug For Elderly Patients
4/20/2023
Examine how an innovative formulation approach helped a developer create a version of their drug that promotes treatment compliance within the geriatric population.
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Effect Of Moisture On Cohesion Strength Of Carboxymethyl Cellulose Powder
4/6/2023
Carboxymethyl cellulose powder is a hygroscopic material used in a variety of applications. Here, the impact of moisture content on cohesion strength is measured using a shear cell accessory.
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Effect Of Moisture And Substrate Material On Wall Friction Angle Of Powder
4/6/2023
Powder rheology is a useful tool for formulating and optimizing pharmaceutical tablet processing conditions. Investigate the influence of moisture content and substrate material on carboxymethyl cellulose powder wall friction.
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How Successful Tech Transfer Can Help Fast-Track NDA Approval
4/4/2023
Examine the first-time-right tech transfer and phase-3 registration batch manufacturing process which led to a biotech receiving NDA approval for its novel compound followed by a successful commercial manufacturing partnership.
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The Impact Of Powder Morphology On Pharmaceutical Excipient Performance
3/31/2023
Gain insight into the processing behavior of two lactose excipients through multiple powder rheology measurements of milled and spray-dried lactose.
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A Novel Thermodynamic Assay For Biomolecular Structure Stability
3/29/2023
This comparability study utilized a nano differential scanning calorimeter to detect biomolecular structure changes in response to subtle manipulations of liquid protein reference formulation.