Formulation Development Applications & Studies
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Streamline Method Validation In Pharmaceutical Product Development
9/21/2022
Method validation is a time-consuming activity prone to human error. Find out how a method validation manager can provide a single, comprehensive solution for your validation activities.
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Method Development of Ten Antibiotic Compounds Using A Systematic Screening Protocol
9/21/2022
Effective method development of LC and LCMS methods typically involve highly experienced scientists with a wealth of knowledge that has been handed down throughout their organization. For some particularly challenging and complex mixtures this experience may not be enough. Learn how Waters leveraged a generic systematic protocol to separate a variety of APIs in a single run.
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Sequencing Of Synthetic Oligonucleotides And Their Impurities
9/20/2022
We demonstrate an automated, compliance-ready liquid chromatography-mass spectrometry (LC-MS) workflow for sequence confirmation of oligonucleotides and their impurities.
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Single-Use Bioreactors For Perfusion Cell Culture Applications
9/9/2022
The work presented here showcases the improved mass transfer performance seen in the 500 L single-use bioreactor and associated cell culture work in continuous perfusion mode.
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Expansion Of Porcine SK-RST Cells On Microcarriers Via Serial Passage In Stirred Vessels
9/7/2022
By performing a small-scale study with multiple microcarrier types and medias we identify the best microcarrier and media for the expansion of porcine SK-RST cells via microcarrier-based serial passage in stirred vessels.
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Development Of A Platform Approach To Binding ELISAs
9/6/2022
We demostrate how to reduce the time taken to develop a binding ELISA from over five runs to just two runs for both IgG monoclonal antibodies and Fc fusion proteins.
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Novel Chemically Defined, Animal Component Free Medium For Vero Cells And Virus Production For Human And Animal Vaccines
9/2/2022
We examinea a chemically defined, serum-free, animal-component free medium that demonstrated excellent results in Vero cell growth and virus yield in both 2D and 3D culture systems.
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SPR Assays To The Assess Similarity Between Innovator And Biosimilar Versions of Nivolumab (Opdivo®)
9/2/2022
Learn more about developed and qualified SPR assays to characterize the binding and affinity of biosimilar and innovator nivolumab for all seven Fc gamma receptors, FcRn and PD-1.
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Expansion Of MRC-5 Cells On Microcarriers Via Serial Passage In Stirred Vessels
9/1/2022
In this application note we characterize MRC-5 cell growth on multiple microcarriers in stirred vessels and present data demonstrating feasibility of serial passage and scale-up into bioreactor expansion of MRC-5 cells.
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Microcarrier Delivery System For Reduced Bioreactor Set Up Time
9/1/2022
This paper evaluates a gamma irradiated, ready-to-use microcarrier delivery system that reduced bioreactor set up time by approximately by 20%.