Liquid Dose Manufacturing Solutions

  1. Pharmaceutical Headspace Oxygen Stability Studies 5/19/2016

    Many of today's biopharmaceutical formulations may potentially suffer from oxidation to some degree. Large molecule formulations are relatively more delicate and may be prone to degrade in the presence of oxygen.  Besides a loss of efficacy and reduction in shelf life, exposure of such products to oxygen can result in product discoloration, changes in dissolution rate and profile, and even toxicity or other pharmacological properties associated with negative side effects. During the development of an oxygen-sensitive product, studies are performed that investigate the formulation’s interaction with oxygen. End-of-shelf-life stability studies verify that the product indeed retains efficacy under specified headspace oxygen levels. Such studies allow for the specification of appropriate initial headspace oxygen levels in the primary packaging.

  2. Pharmaceutical Powder/Fume Hood System 3/26/2019

    Combination Powder and Fume Hood with HEPA filtration and house exhaust connection designed to process liquid and powder substances. Fume Hood designed to house stir plate and analytical balance. It features cup sink; air, water, and gas fittings; and alarm for monitoring and maintaining recommended face velocity of 75 LFPM. Fume and Powder Hoods separated by sliding door to eliminate cross-contamination during processing. Powder Hood uses front airfoils and rear plenums to maintain laminar airflow across the work surface, which is vented through a HEPA filtration system to house exhaust.

  3. Pharmaceutical Aseptic Filling Isolator: IsoSphere 6/24/2019

    The IsoSphere-AF is a positive pressure unidirectional airflow isolator or RABS for small, medium and large volume aseptic filling.

  4. Used Capmatic Pharmaceutical Vial Filling: Conquest FS8 7/10/2024

    Used Capmatic inline vial filling line, model Conquest FS8 consisting of: 36" Capmatic accumulation table, serial# TT01110917: Model Conquest FS8 Capmatic inline filler, (16) head walking beam filling station with (8) piston fill pumps, integrated chain conveyor and rotary stopper feed system with vibrating bowl feeder, Allen Bradly Panelview 1000 HMI, serial# CQ1110919, built 2002: Model R-R Pharma Capmatic crimp capper, type RoadRunner, (12) station with Capmatic cap elevator, Allen Bradley PLC controls and Panelveiw 900 HMI, serial# RR00030718, built 2003: Capmatic dual position tray loader, serial# TT02020846, built 2002.

  5. BD Neopak XSi Glass Prefillable Syringe 11/8/2021

    BD Neopak™ XSi™ Glass Prefillable Syringes have been designed for improved integrity of the lubricant layer reducing subvisible particle level of biologic formulation in PFSs, particularly for drugs that may be very sensitive to silicone oil.

  6. Aseptic Filling Systems For Biopharmaceutical Manufacturing 3/28/2023

    AST aseptic filling products address the unique processing requirements of biologics manufacturing to gently care for biologic products during the fill-finish process. Their highly accurate peristaltic dosing system uses single-use pharmaceutical grade tubing that has been optimized to keep shear stress to an absolute minimum. When exiting the fluid path through the filling needle, the motion control system maintains the fill needle within the container and slowly rises as the product is being dispensed to minimize splashing and foaming that could introduce stress to the product. Temperature controlled filling is also possible with the ASEPTiCell® and GENiSYS® systems. AST has experience dosing products at temperatures as low as 3°C.

  7. BD Physioject™ Disposable Autoinjector 6/26/2025

    BD Physioject™ Disposable Autoinjector offers a proven, user-friendly platform for self-injection, enhancing patient comfort, safety, and adherence across multiple chronic disease treatments globally.

  8. Hybrid Isolator – Dual Purpose Vented Enclosure 6/8/2019

    Hybrid Isolator series (EHP and EHG) provides containment for highly toxic applications using APIs and HPAPIs that require personnel and/or product protection.

  9. Used Adtech Pharmaceutical Syringe Filling System 7/23/2019

    Used Adtech syringe filler, SO# 725, with visual inspection system, capper feeder, Allen-Bradley PLC and interface, built 1989.

  10. From DSP Buffers To Dangerous Goods: One Single Source 4/7/2021

    In the manufacturing of biopharmaceuticals purification steps are critical to the process; therefore the equipment and consumables used must be of the highest quality standards. To ensure a robust supply chain, we have capabilities to produce all the formulations required for the wide variety of applications in downstream processing.