Formulation Development

A Guide To Bioavailability Enhancement

Many new drug candidates face oral bioavailability challenges. Particle engineering, lipid systems, and inclusion complexes can boost absorption, though patient variability remains a hurdle.

A Strategic Guide For Challenging Early-Phase Molecules

Early formulation decisions for high-viscosity, unstable, and potent molecules impact scale-up, regulatory flexibility, and lifecycle value. Getting them right early helps avoid costly rework.

Advancing The Development Of Syringe-Device Combinations

Defining the design for syringe-autoinjector pairings early, through shared compatibility testing, can reduce integration risk for high-viscosity biologics intended for self-administration at home.

Nasal Delivery Of Psychedelics: Next Generation Delivery Options

Psychedelic development has moved past regulatory hurdles to a question of formulation and delivery. For fast-acting molecules, dosing control and onset speed are pushing developers toward one route.

Early Automation Integration Reshapes How Drugs Move

Introducing automation during R&D rather than in Phase 3 changes how processes scale. Unified data and standards-based control logic carry across bench, pilot, and commercial stages with less rework.

Long-Acting GnRH Antagonist For Advanced Prostate Cancer

Achieve rapid testosterone suppression for 6+ months with a novel low-volume subcutaneous depot formulation, eliminating the initial surge and offering a new approach for advanced prostate cancer treatment.

Why Early Device Decisions Matter: How Immunovant Accelerated Its Program

Deferring autoinjector selection can seem to preserve flexibility, yet it often moves constraints downstream. Integrating the device during Phase IIb changed one program's timeline and removed bridging work.

Using Human-Centered Engineering To Improve HPLC Solvent Handling

Real-world HPLC workflows show how closed-system solvent handling can address contamination, downtime, and waste across laboratory settings.

Reducing Cycle Time By 88% Through Strategic Solvent Replacement In Pharmaceutical Development

Replacing methylene chloride in a slow, labor-intensive API step led to a single-solvent, one-pot process with a shorter reaction time and improved yield and purity.

Improving Stability Through Science-Led OSD Reformulation

A marketed multivitamin tablet spanning a 0.03% to 46% w/w range failed early in accelerated stability testing. Mechanism-led reformulation and a switch to direct compression changed the outcome.