Formulation Development
FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES
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Why Controlled Release Is Essential For Patient-centric Drug Development
Controlled release design can ease daily dosing burden by moderating swings in drug exposure, though the right approach depends on API properties and what manufacturing can deliver at scale.
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Everyday Medicines, Complex Manufacturing: 5 Reasons They Aren't Simple To Make
Tablets and liquid medicines look simple to the patient, but their reliability depends on formulation choices made early and on technical expertise that continues well after commercial production begins.
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Why Reagent Quality Defines Research Success
Water grade, buffer preparation, and packaging each shape whether sensitive assays hold up. Reagent selection hinges on matching purity to application sensitivity, regulatory standards, and tolerance for contamination risk.
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Peptide Building Blocks: Navigating Quality, Supply, And Scale
Non-canonical amino acids can boost peptide half-life and potency, but create challenges in impurity control, GMP classification, and sourcing. Early supplier choices are critical for commercialization.
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Accelerating Complex Generic Drug Development Through Advanced Deformulation
With FDA no longer identifying Q1/Q2 differences, applicants bear the diagnostic burden. Reverse engineering now directly affects development speed, cost, and approval.
FORMULATION DEVELOPMENT APPLICATIONS & STUDIES
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Why Early Device Decisions Matter: How Immunovant Accelerated Its Program
Deferring autoinjector selection can seem to preserve flexibility, yet it often moves constraints downstream. Integrating the device during Phase IIb changed one program's timeline and removed bridging work.
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Using Human-Centered Engineering To Improve HPLC Solvent Handling
Real-world HPLC workflows show how closed-system solvent handling can address contamination, downtime, and waste across laboratory settings.
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Reducing Cycle Time By 88% Through Strategic Solvent Replacement In Pharmaceutical Development
Replacing methylene chloride in a slow, labor-intensive API step led to a single-solvent, one-pot process with a shorter reaction time and improved yield and purity.
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Improving Stability Through Science-Led OSD Reformulation
A marketed multivitamin tablet spanning a 0.03% to 46% w/w range failed early in accelerated stability testing. Mechanism-led reformulation and a switch to direct compression changed the outcome.
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De-Risking Complex Generic OSD Development
Complex generic tablet development requires early alignment of regulatory strategy, QbD formulation, discriminatory dissolution, and reference-scaled bioequivalence.
FORMULATION DEVELOPMENT SOLUTIONS
- Keep A Close Eye On Quality With Excipients For Drug Formulation
- Custom Organ-Chip Models For A Wide Variety Of Applications
- HyClone™ Peak Expression Medium
- Pre-Formulation And Material Sciences
- High-Throughput Cellular Screening System
- Small Molecule Drug Substance: API Capabilities
- Are You In Control Of Your Protein Galactosylation Profile?
- Multi-Mode Microplate Reader
- LC And LC-MS Chemistry Consumables For Bioseparations
- Protect Your Lab Instruments From Expected Downtime With FlexCHOICE Service Coverage
PHARMACEUTICAL AND FORMULATION DEVELOPMENT NEWS
- Hapman To Unveil New Conveying Solution At PACK EXPO 2026
- Pharmaceutical Online Covers Honorable Mention FOYA Award Winner, Chugai Pharmaceutical Co., Ltd.
- Emerson Expands Life Sciences Scheduling Software To Optimize Quality Control Lab Testing
- GSK Announces Drug Manufacturing Expansion In Pennsylvania
- Contec Launches Sterile ReadySAT™ With PeridoxRTU® Sporicidal Wipes For Cleanrooms
- Upperton Unveils New Brand Identity Reflecting Evolution Into Specialist CDMO
- Hovione To Commission World's First ConsiGma® CDC Flex, Bringing Next-Generation Continuous Tableting To The U.S.
- Agilent Expands Oligonucleotide Manufacturing Capabilities With New Boulder Lab
- Flamma Acquires API Manufacturing Site In Padova, Italy
- Bayer Expanding U.S. Pharmaceutical Manufacturing Footprint With New Ohio Manufacturing Facility