Formulation Development
FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES
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Beyond PMI: Solvents As A Key To Sustainable Process Design
Discover how data-driven solvent selection helps uncover sustainability opportunities, boost efficiency, and enable smarter process optimization decisions.
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How Data-Driven Development Is Transforming Phosphoramidites
High-quality phosphoramidites are key to oligonucleotide therapies. Learn how data-driven optimization boosts purity, streamlines manufacturing, speeds scale-up, and supports commercialization.
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Three Keys To E&L Success: Study Design, Partner Selection, And Timing
Successful E&L planning starts before testing begins. Aligning study design, partner expertise, and timing helps teams focus on the right risks, avoid surprises, and support stronger development.
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Patented Process For Olopatadine HCl API Intermediates
See how this patented Wittig-based process for olopatadine HCl achieves Z/E isomer ratios up to 4:1, eliminating dangerous reagents like n-butyl lithium while cutting purification complexity.
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Platform Strategy For Improving Manufacturability And Efficacy In Bispecific Antibodies
Novel bispecific antibody engineering overcomes assembly and manufacturability challenges, enabling scalable production while preserving therapeutic function, stability, purity, and product quality.
FORMULATION DEVELOPMENT APPLICATIONS & STUDIES
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Predicting Food Effects In Oral Drug Delivery Using PBPK Modeling
Learn how integrated PBPK and molecular dynamics modeling predicted an ~11% fed-state Cmax increase for fenofibrate, giving formulation teams earlier, mechanistic insight into food-dependent absorption.
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Compaction Simulation For Tablet Technology Transfer And Scale-Up
Compaction simulation de-risked tech transfer for a 40 mg fexuprazan tablet by defining optimal roller compaction and lubrication parameters before scale-up. Access the full case study to see the data.
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Predicting Softgel Stability And Shelf Life Using Accelerated Modeling
Predict ibuprofen softgel shelf life in 21 days instead of years. ASAPprime modeling identified PEG-ester degradants as the limiting factor, estimating 5.5-year and 3.8-year shelf lives before long-term studies concluded.
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Predicting Drug-Loading Limits In Tablet Formulations
Learn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.
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Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies
In silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.
FORMULATION DEVELOPMENT SOLUTIONS
- Single-Use Automated Virus Filtration System
- Integrated Programs To Bridge Molecules From Discovery Into Clinical Development
- Drug-Drug Interaction (DDI) Studies
- Intelligent, Precise, And Scalable Automation Solution For 3D Biology
- Granulated Materials: Easy Handling For Improved Process Efficiency
- Expediting Drug Discovery From Concept To Commercialization
- Magnetic Mixer System
- Allegro™ Ready Filter Sets
- Your End-To-End CDMO Partner
- Comprehensive ADC And Bioconjugation Services For Targeted Therapies
PHARMACEUTICAL AND FORMULATION DEVELOPMENT NEWS
- Amneal's Planned Sterile Facility Creates Opportunity For Aseptic Filling, Isolator, And Automation Suppliers
- Lonza Expands HPAPI Capacity In Visp, Further Supporting Its Position In Payload-Linker Manufacturing
- AustinPx Expands KinetiSol™ Technology Commercial Access Through Thermo Fisher Scientific Collaboration
- Recipharm Invests In U.S. Fill-Finish Infrastructure To Accelerate Biologics Development
- Four Myths About Embedded CMOs, Busted
- Avoiding Recalls: How To Ensure Sterility In Ophthalmic Products
- Veranova Appoints Dr. Bob Huang Vice President And General Manager Of West Deptford Site
- Leica Biosystems And CellCarta Expand Collaborative Companion Diagnostic Development Model To Accelerate Commercialization Globally
- Quotient Sciences Advances AI-Designed Drug Product Into Clinical Development
- ILC Dover Expands Life Sciences Presence With Water For Injection (WFI) And Custom Chemical Solutions