Formulation Development
FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES
-
Peptide Building Blocks: Navigating Quality, Supply, And Scale
Non-canonical amino acids can boost peptide half-life and potency, but create challenges in impurity control, GMP classification, and sourcing. Early supplier choices are critical for commercialization.
-
Why Audit Success No Longer Predicts Clinical-Stage Performance
Passing inspections no longer signals that a growth-stage biotech can sustain clinical-stage complexity. The gap between audit readiness and operational readiness opens quietly.
-
Practical Formulation Strategies For Poorly Soluble APIs
Poor aqueous solubility now defines most drug candidates in development, making early screening and solid-state assessment essential to achieving reliable exposure and avoiding costly reformulation downstream.
-
The Art Of Protein Expression: A Guide To Understanding Difficult-To-Express Proteins
Protein expression failures often result from misfolding, PTMs, assembly issues, insolubility, and toxicity. Understanding their interplay can improve yields.
-
The Continuing Challenge Of Drug-Induced Liver Injury
Recent liver safety concerns highlight the limits of conventional preclinical testing. Human-relevant models could help researchers detect drug-induced liver injury earlier and reduce costly setbacks.
FORMULATION DEVELOPMENT APPLICATIONS & STUDIES
-
Reducing Cycle Time By 88% Through Strategic Solvent Replacement In Pharmaceutical Development
Replacing methylene chloride in a slow, labor-intensive API step led to a single-solvent, one-pot process with a shorter reaction time and improved yield and purity.
-
Formulation And Process Challenges For A Needle-Shaped API
Managing challenging active pharmaceutical ingredient crystal structures and choosing dry granulation over wet granulation requires strategic processing choices.
-
From Sequence To Scale In Seven Months
Accelerate recombinant protein development from sequence to scale while maintaining stable expression, manufacturing efficiency, and critical quality attributes.
-
Characterizing Protein Stability By DSC
Discover how differential scanning calorimetry quantifies the thermodynamic forces behind protein folding and stability, providing valuable insight for protein engineering and therapeutic formulation.
-
Life Science Applications Of DSC
Learn how Differential Scanning Calorimetry directly measures macromolecular stability, unfolding, and binding interactions, providing valuable thermodynamic insights for protein engineering.
FORMULATION DEVELOPMENT SOLUTIONS
- Four Keys To Great Bioanalytical Methods
- Control Your Bioprocess Development: Faster Decisions With Quality Data
- Dynamic And Ergonomic Oligosynthesis Column
- Addressing Your Requirements For Parenteral Applications
- High Resolution Mass Spectrometric Analysis Of Complex Biotherapeutics
- A Human-Relevant Liver Model With Minimal Drug Absorption
- Method Optimization
- Gibco Media And Feeds Selection Guide
- Chip-R1™ Basic Research Kit
- Peptide Crystallization
PHARMACEUTICAL AND FORMULATION DEVELOPMENT NEWS
- Pharmaceutical Online Covers Honorable Mention FOYA Award Winner, Chugai Pharmaceutical Co., Ltd.
- Emerson Expands Life Sciences Scheduling Software To Optimize Quality Control Lab Testing
- GSK Announces Drug Manufacturing Expansion In Pennsylvania
- Contec Launches Sterile ReadySAT™ With PeridoxRTU® Sporicidal Wipes For Cleanrooms
- Upperton Unveils New Brand Identity Reflecting Evolution Into Specialist CDMO
- Hovione To Commission World's First ConsiGma® CDC Flex, Bringing Next-Generation Continuous Tableting To The U.S.
- Agilent Expands Oligonucleotide Manufacturing Capabilities With New Boulder Lab
- Flamma Acquires API Manufacturing Site In Padova, Italy
- Bayer Expanding U.S. Pharmaceutical Manufacturing Footprint With New Ohio Manufacturing Facility
- ROSS 600-Gallon ASME Pressure Vessel For High-Pressure Processing