This whitepaper describes how deploying such a platform can provide end-to-end visibility across Pre-formulations and Formulations Development and expedite the identification and progression of safe, efficacious formulations.
Drug delivery as solid dosage forms is complex with a number of factors that can noticeably influence their therapeutic benefit. The drug must be stabilized in the tablet and at the same time be available for absorption in a short time after dosing . The formulation and design of soluble oral tablets needs several factors to be considered.
R&D spending in the pharmaceutical industry through 2015 was valued at around $58bn as organisations vied to gain a competitive advantage by bringing new drugs to market as quickly as possible. Materials science is now helping pharmaceutical companies to standardize and control areas such as drug form and manufacture to deliver new products more quickly and with greater quality. The pharma industry is increasingly embracing the principles of Quality by Design (QbD) to improve efficiency and ensure good quality and reduced variability throughout the drug production process.
At the early stages of product development, pharmaceutical development scientists are under increasing time pressure to select the right molecule form, the right formulation and the right final dose form.
This whitepaper introduces the concept of the electronic Development Record (eDR) and how it can propel the development process forwards, reduce costs, and improve quality.
While the wider use of opioids has led to many benefits for patients in pain, it also has led to higher incidences of misuse, abuse, and development of opioid addiction. To address this issue without preventing legitimate patients from receiving their necessary medication, Grünenthal set out to create an abuse-deterrent formulation with a technology that creates a physico-chemical barrier to abuse and, as a result, safeguards patients from the battle of addiction.
Use technology to achieve desired product performance.
Moisturizing creams will be defined by their viscosity or thickness. Formulating moisturizing creams depends on the required end product consistency, influencing the choice of material to use.
Anton Paar's Generation M density meters and Abbemat refractometers deliver accurate and repeatable measurement results while providing system security for 21 CFR Part 11 compliance.
One tool holds a unique position among R&D informatics systems. Unlike other systems, electronic laboratory notebooks (ELNs) both produce data and consume information. An ELN’s ability to capture data, observations, experiences, and context is particularly powerful when combined with other data pipelining tools. The ability to link key pieces of data and mine experiments captured in the ELN for insights fuels true scientific knowledge management. This use case describes the broad organizational benefits that BIOVIA Workbook made possible for a global pharmaceutical company, highlighting how the system is supporting efforts to gain predictive control over key processes in Research and Development.