Formulation Development

Whether you require a particular expertise or a complete, experienced integrated small molecule discovery team, Curia can provide a high-performance solution to help turn your vision into reality.

LMD 6 Laser Microdissection Microscope

Dissection Perfection

Laser Microdissection (LMD, also known as Laser Capture Microdissection or LCM) enables users to isolate specific single cells or entire areas of tissue. Powered by a unique laser design and dynamic software, Leica LMD systems allow users to easily isolate Regions of Interest (ROI) from entire areas of tissue down to single cells or even subcellular structures such as chromosomes.

LMD is typically used in genomics (DNA), transcriptomics (mRNA, miRNA), proteomics, metabolomics, and even next generation sequencing (NGS). Researchers in neurology, cancer research, plant analysis, forensics or climate research rely on this method. Furthermore, LMD is a perfect tool for live cell culture (LCC), for cloning and re-cultivation, manipulation or downstream analysis.

We move the laser, not the sample. And we use gravity for collection. That is why our LMD systems provide you with perfectly cut, contamination-free, analysis-ready dissectates.

Understand Your Biotransformation Data

MetaSense helps you make sense of all your metabolite identification (MetID) data. Move beyond complex workflows that have you flipping back and forth between a dozen programs.

With a single interface for prediction, data analysis, and knowledge dashboards, make data-driven decisions swiftly.

• Collect all your MetID data and view it in one place
• Auto-generate biotransformation maps and kinetic plots
• Click between interactively linked maps and plots to see your data at any depth
• Reprocess data directly from MetaSense
• Draw conclusions about a drug candidate’s metabolism and viability

Curia’s DMPK scientists deliver expert solutions for your drug discovery programs. Providing bioanalytical methods development, in vitro ADMET testing and in vivo PK and PD services that span all stages of drug discovery up to candidate selection.

Rigaku Miniflex X-Ray defractor, (6) sample capacity, water cooled, 115 volts, serial# TD01111.

Filterless readers provide consistent results with steady temperature regulation

The SpectraMax® ABS and ABS Plus absorbance microplate readers provide the flexibility, sensitivity, and convenience for a wide range of assays such as ELISAs, microbial growth, and protein quantitation. Both readers feature an 8-channel read head for fast reads and a subset feature, the temperature independent PathCheck sensor that automatically normalizes and ensures accurate absorbance values by detecting pipetting errors. Combined with a wide application base, industry-leading SoftMax® Pro Software and validation tools, these readers fit in every lab and every budget.

Multicolor Multiphoton gets you closer to the truth

The combination of multiple distinct fluorescent labels is increasingly used to study dynamic interaction and spatial relationships among cells and molecules. The goal is to understand a myriad of complex biological events, such as cellular connectivity, cell phenotyping, protein interaction or co-expression, and co-localization. Scaling up such studies to whole organs or tissues requires suitable large-volume multicolor microscopy methods. DIVE and STELLARIS have now merged to provide you with the power of flexible multicolor multiphoton imaging. Furthermore, you can expand the potential of your experiments with additional label-free imaging capabilities.

Seamlessly integrated into the confocal software interface, STELLARIS 8 DIVE multiphoton microscope offers the benefits of high speed and excellent navigation so that dynamic processes in complex samples can be studied with ease. STELLARIS 8 DIVE – A rainbow of possibilities for your research.

Nanoform’s award-winning Controlled Expansion of Supercritical Solutions (CESS®) technology is a bottom-up nanoparticle engineering approach that enables the creation of API nanoparticles and can unlock the full therapeutic potential of small molecule drugs.