Formulation Development

FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES

FORMULATION DEVELOPMENT APPLICATIONS & STUDIES

  • Using DSC And MDSC To Study Material Interactions Of APIs And Excipients

    Thermal analysis reveals how particle size and morphology influence material interactions and stability. Learn how DSC and MDSC techniques uncover compatibility issues and guide better excipient selection.

  • Remote Measurements For Bulk Samples

    Remote Raman spectroscopy enables accurate material identification at long distances without complex focusing. Learn how pathlength, sample properties, and substrate choice impact signal quality.

  • Lentiviral Vector Upstream Process

    Scalable lentiviral vector production is moving beyond adherent systems. Learn how streamlined workflows enable linear scale-up in stirred-tank bioreactors for cost-effective gene therapy manufacturing.

  • Aggregate Analysis Of Tirzepatide

    A new size exclusion method effectively analyzes Tirzepatide aggregates, demonstrating robust separation and reproducibility with minimal need for organic solvents or acidic modifiers.

  • Aggregate Analysis Of Semaglutide

    Effective size exclusion chromatography (SEC) for Semaglutide aggregate analysis is possible without high organic solvents or acidic modifiers. Learn about this robust method for improved efficacy.

FORMULATION DEVELOPMENT PRODUCTS & SERVICES

A60 F Stereo Microscope 

Optimize your productivity and production quality

The intuitive A60 F and A60 S stereo microscopes fulfill what you need – high sample throughput, optimum visibility of product details and components, and easy processing of subassemblies.

  • See 80% more of your sample with a 46 mm object field

  • Comfortable access your sample due to the 122 mm working distance

  • Easy handling, less refocusing and time saving with up to 13.6 mm depth of field and Leica FusionOptics technology

  • Enables large surface overview and detailed observation with a magnification range from 5x to 30x

When it comes to solid dosage formulations, the most common challenge formulators face is poor solubility. In numbers: 70% of drugs in development are poorly soluble.

Encoded stereo microscopes Leica M165 C​ - Total recall of your settings

Your goal: high-quality images that allow measurements and can be accurately repeated with minimal effort. The Leica coded stereo microscopes help you to pave the way to correct results.

  • Coded microscopes consistently deliver calibrated and comparable images

  • Reproduce images in moments with the Leica “Store and Recall” function

  • Fully apochromatic corrected zoom optics deliver high quality images

  • Customize the microscope system to your task with the exclusive range of accessories

Powerful tools for characterizing protein-protein interactions, structural stability, and formulation compatibility.

Access the future of AI microscopy

Subjectivity of analysis and poor reproducibility are key hurdles to be overcome for biological image analysis. Standard segmentation can lead to sub-standard results and require substantial manual curation which is subject to human error.

LMD 6 Laser Microdissection Microscope

Dissection Perfection

Laser Microdissection (LMD, also known as Laser Capture Microdissection or LCM) enables users to isolate specific single cells or entire areas of tissue. Powered by a unique laser design and dynamic software, Leica LMD systems allow users to easily isolate Regions of Interest (ROI) from entire areas of tissue down to single cells or even subcellular structures such as chromosomes.

LMD is typically used in genomics (DNA), transcriptomics (mRNA, miRNA), proteomics, metabolomics, and even next generation sequencing (NGS). Researchers in neurology, cancer research, plant analysis, forensics or climate research rely on this method. Furthermore, LMD is a perfect tool for live cell culture (LCC), for cloning and re-cultivation, manipulation or downstream analysis.

We move the laser, not the sample. And we use gravity for collection. That is why our LMD systems provide you with perfectly cut, contamination-free, analysis-ready dissectates.

THUNDER Imager Live Cell & 3D Assay

Decode 3D biology in real time*

With THUNDER Imagers you begin every experiment with confidence. They are your solution for advanced 3D cell culture assays, whether you want to study stem cells, spheroids, or organoids.

Uniquely Ergonomic System Microscopes With Intelligent Automation Leica DM3000 LED

Enhance Laboratory Workflow

The Leica DM3000 LED microscopes for pathology, cytology, haematology and many other applications feature a motorized nosepiece, condenser head, automated light intensity adjustment, and optional foot pedal. These intuitive microscopes improve workflows significantly. For special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) like in-vitro-fertilization (IVF).