Formulation Development

FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES

  • Best Practices For A Successful Bioprocess Technology Transfer
    Best Practices For A Successful Bioprocess Technology Transfer

    A well-executed bioprocess technology transfer (tech transfer) is critical to ensure smooth knowledge transfer and optimal process reproducibility. If not executed properly, you risk reducing the quality and efficiency of your process. Waste time trouble shooting, and you may delay your time to market. In today’s global markets effective tech transfer is critical.

  • Data Gathering And Analysis Necessary In New Tablet Development
    Data Gathering And Analysis Necessary In New Tablet Development

    A significant concern in tablet manufacturing is speed to market. Moving too quickly, however, may cause delayed production, lost product, and missed deadlines. To reduce potential headaches, companies are embracing the principles of Quality by Design (QbD) and utilizing automated data gathering and tablet analysis during research and development. This allows organizations to reduce product development and delivery stress and loss.

  • Designing In-Vitro Dissolution Test Conditions During Early Phase Formulation Development
    Designing In-Vitro Dissolution Test Conditions During Early Phase Formulation Development

    Deriving in vitro dissolution test conditions represents a challenging area for many organizations progressing through early stage development. Unfortunately, the stakes here are high. Inappropriate dissolution test conditions during early phase formulation development may lead to a partial or complete failure of desired bioavailability in vivo.

  • Overcoming Bioavailability Challenges In Oral Formulation Development
    Overcoming Bioavailability Challenges In Oral Formulation Development

    With nearly 90 percent of the developmental pipeline drugs consisting of poorly soluble molecules, formulation experts must be prepared to address this obstacle by applying various approaches to improve an API’s pharmacokinetics. 

  • Now & Next: Mavupharma
    Now & Next: Mavupharma

    Saurabh Kapure, Vice President, Business Development, USA for Jubilant Biosys, recently sat down with Michael Gallatin, Ph.D., president and co-founder of Mavupharma (Mavu), the drug discovery and development company, to discuss some of the latest developments in the industry and at Mavu. In this Q&A, Dr. Gallatin shares his thoughts about Mavupharma, his role at the company, the evolution of biopharma, drug discovery, development, and the road ahead for the industry with Saurabh.

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FORMULATION DEVELOPMENT APPLICATIONS & STUDIES

  • Precise Control Of Gas Flows Within The BIOSTAT® B-DCU
    Precise Control Of Gas Flows Within The BIOSTAT® B-DCU

    To meet the oxygen demand of cells a stable pO2 control is an essential part of every cultivation. The objective of this application note is to demonstrate the performance of a new generation of mass flow controllers in the BIOSTAT® B-DCU bioreactor system. Several comparative cell cultivations were performed.

  • Automated Glucose Control
    Automated Glucose Control

    Within this application is an example method on how to establish glucose feed control is documented and as well as highlighting the key benefits of applying this method to other processes.

  • Closed And Semi-Automated Processing Of CAR T Cells
    Closed And Semi-Automated Processing Of CAR T Cells

    Challenges of T cell immunotherapies include the costly manufacturing process relying on lengthy and complex open workflows with high manual labor requirements that influence product variability. This application note describes the details of a robust CAR T cell manufacturing workflow that can be adapted for cGMP compliance in commercial production of CAR T cells.

  • S.U.B. Enhancements For High-Density Perfusion Cultures
    S.U.B. Enhancements For High-Density Perfusion Cultures

    This study presents how strategic enhancements to the sparge and agitation systems of Thermo Scientific HyPerforma S.U.B.s have revealed the potential for a three- to four-fold improvement in mixing and mass transfer performance compared to legacy S.U.B. designs.

  • Improved Bioavailability Of Trio Medicines In 12 Weeks
    Improved Bioavailability Of Trio Medicines In 12 Weeks

    Learn how a structured 3-step approach can help overcome the challenge of molecular characterization and a limited budget.

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FORMULATION DEVELOPMENT PRODUCTS & SERVICES

Micro Ultracentrifuges Micro Ultracentrifuges

NuAire is pleased to partner with the reputable brand Hitachi Koki to offer our customers sales and support of table top and floor standing Mirco Ultracentrifuges in the North American market.

Jet Feeder System for Powder Feeding and Mixing Jet Feeder System for Powder Feeding and Mixing

The Jet Feeder is a multi purpose system for feeding powders into liquid and for low shear mixing. It is the perfect unit to use on those products that are sensitive to shear. ILC Dover completed a successful test at a pharmaceutical facility for mixing starch into solution for a tableting process. The system is cGMP, easy to clean or CIP, and will work in single pass processes or recirculating processes. JetSolutions is an ILC Dover company and is the manufacturer of the Jet Feeder.

Ultracentrifuge Ultracentrifuge

The CP100WX is a general-purpose Ultracentrifuge with outstanding performance up to 100,000 rpm assisting in a wide range of separation protocols in involving proteins, DNA, RNA, metal nano-colloids, and more. Reliable and efficient the Hitachi CP100WX features a Rotor Life Management (RLM) system to automatically maintain rotor logging history maximizing rotor life.

Zetasizer Pro Nanoparticle Size Analyzer Zetasizer Pro Nanoparticle Size Analyzer

Nanoparticle size analyzer with zeta potential measurements.

The Zetasizer Pro is a robust and versatile system for the measurement of particle and molecular size and electrophoretic mobility and zeta potential of nanoparticles.

CR22N High-Speed Refrigerated Centrifuge CR22N High-Speed Refrigerated Centrifuge

The Hitachi Koki model himac CR22N High-Speed Refrigerated Centrifuge offers reliable performance with a maximum RCF of 55,200xg and capacity of 6L for bottles, tubes, or microplates. Patented features such as the Automatic Rotor Identification and Rotor Cover Detector make the CR22N the ideal separation tool for multiple research applications involving DNA, RNA, viruses, proteins, and more.

Laboratory Centrifuges Laboratory Centrifuges

NuAire benchtop centrifuges offer mono and multi functionality, refrigerated and non-refrigerated models. Technical innovations optimize productivity in your laboratory work to improve results, save time, while providing a greater relative centrifugal force (RFC).

Microcentrifuge Microcentrifuge

NuAire offers ventilated and refrigerated micro-centrifuges ideal for high and low speed applications for small sample volumes.

Mini Microcentrifuge  - Prism™ LN-C1801 Mini Microcentrifuge - Prism™ LN-C1801

The user-friendly Prism™ Mini is a reliable, compact, and economical personal microcentrifuge ideal for quick spins that can be used for a wide range of molecular biology protocols. Prism™ Mini works out of the box with a maintenance-free drive system and advanced design providing quiet operation and proper ventilation protecting temperature-sensitive samples. Prism™ Mini includes two (2) quick release interchangeable rotors with a max speed up to 6000 RPM.

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