Formulation Development
FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES
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![pharmaceutical factory equipment-GettyImages-499694183]( "Beyond PMI: Solvents As A Key To Sustainable Process Design")
Beyond PMI: Solvents As A Key To Sustainable Process DesignDiscover how data-driven solvent selection helps uncover sustainability opportunities, boost efficiency, and enable smarter process optimization decisions.
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![Oligonucleotides-GettyImages-2234236209]( "How Data-Driven Development Is Transforming Phosphoramidites")
How Data-Driven Development Is Transforming PhosphoramiditesHigh-quality phosphoramidites are key to oligonucleotide therapies. Learn how data-driven optimization boosts purity, streamlines manufacturing, speeds scale-up, and supports commercialization.
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![pharma-partners-GettyImages-2182052451]( "Three Keys To E&L Success: Study Design, Partner Selection, And Timing")
Three Keys To E&L Success: Study Design, Partner Selection, And TimingSuccessful E&L planning starts before testing begins. Aligning study design, partner expertise, and timing helps teams focus on the right risks, avoid surprises, and support stronger development.
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![Strategies For API Solubility And Bioavailability Enhancement: Selecting Technologies And Excipients]( "Patented Process For Olopatadine HCl API Intermediates")
Patented Process For Olopatadine HCl API IntermediatesSee how this patented Wittig-based process for olopatadine HCl achieves Z/E isomer ratios up to 4:1, eliminating dangerous reagents like n-butyl lithium while cutting purification complexity.
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![Reference_image_1]( "Platform Strategy For Improving Manufacturability And Efficacy In Bispecific Antibodies")
Platform Strategy For Improving Manufacturability And Efficacy In Bispecific AntibodiesNovel bispecific antibody engineering overcomes assembly and manufacturability challenges, enabling scalable production while preserving therapeutic function, stability, purity, and product quality.
FORMULATION DEVELOPMENT APPLICATIONS & STUDIES
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![Intestinal tract with digestive health-GettyImages-1985026058]( "Predicting Food Effects In Oral Drug Delivery Using PBPK Modeling")
Predicting Food Effects In Oral Drug Delivery Using PBPK ModelingLearn how integrated PBPK and molecular dynamics modeling predicted an ~11% fed-state Cmax increase for fenofibrate, giving formulation teams earlier, mechanistic insight into food-dependent absorption.
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![GettyImages-163720603 tablet press, OSD]( "Compaction Simulation For Tablet Technology Transfer And Scale-Up")
Compaction Simulation For Tablet Technology Transfer And Scale-UpCompaction simulation de-risked tech transfer for a 40 mg fexuprazan tablet by defining optimal roller compaction and lubrication parameters before scale-up. Access the full case study to see the data.
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![GettyImages-1365580848-ubiquinol-softgel]( "Predicting Softgel Stability And Shelf Life Using Accelerated Modeling")
Predicting Softgel Stability And Shelf Life Using Accelerated ModelingPredict ibuprofen softgel shelf life in 21 days instead of years. ASAPprime modeling identified PEG-ester degradants as the limiting factor, estimating 5.5-year and 3.8-year shelf lives before long-term studies concluded.
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![White Tablets-GettyImages-172969989]( "Predicting Drug-Loading Limits In Tablet Formulations")
Predicting Drug-Loading Limits In Tablet FormulationsLearn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.
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![GettyImages-498013412-laboratory-flask-water-solubility-dropper]( "Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies")
Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement StrategiesIn silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.
FORMULATION DEVELOPMENT PRODUCTS & SERVICES
Power. Potential. Productivity.
STELLARIS 5 is a completely re-imagined confocal microscope platform.
STELLARIS confocal microscopes can be combined with all Leica modalities, including FLIM, STED, DLS, and CRS. With the STELLARIS confocal platform, we have re-imagined confocal microscopy to get you closer to the truth.
- Power to see more
- Potential to discover more
- Productivity to do more
THUNDER Imager EM Cryo CLEM
In-depth understanding of cellular structural biology
The THUNDER Imager EM Cryo CLEM is a cryo light microscope featuring opto-digital THUNDER technology. It provides the imaging data and secure cryo conditions you need for successful experimental investigations concerning structural biology. Precisely identify cellular structures of interest thanks to high resolution, haze-free imaging with THUNDER technology, then transfer the specimen seamlessly to your EM.
Routine cell culture? Check!
For researchers who need consistent experimental outcomes, Mateo TL enables all lab members to check and document cell growth status conveniently and comfortably.
Measure confluency consistently, thereby increasing the confidence in the success of their downstream experiments.
The systems can be provided in sterile, toxic or sterile toxic arrangements with the great advantage of being 100 % scalable.
Curia’s discovery biology team accelerates your program toward the clinic and commercialization with our best-in-class, customizable solutions.
Are you using obsolete or aging instruments simply because they continue to work? Running your laboratory with outdated technology brings about challenges beyond just headaches. Older technology may limit your performance, increase your costs, and open your lab up to risk. It may be time to investigate the real cost of using obsolete technology.
With the Waters FlexUP Technology Renewal Program, always work with the latest technology for optimum productivity and security.
Rigaku Miniflex X-Ray defractor, (6) sample capacity, water cooled, 115 volts, serial# TD01111.
Overcome shared lab challenges with the Avanti JXN-30 high-speed centrifuge
- 4.0 L Max Capacity
- 30,000 RPM
- 110,510 x g
FORMULATION DEVELOPMENT SOLUTIONS
- HyClone™ Peak Expression Medium
- Sterile Drug Product
- A Human-Relevant Liver Model With Minimal Drug Absorption
- How Product Quality Translates To Better Results
- Custom Organ-Chips For 3D Gel Matrices And Direct Compound Dosing
- A Revolutionary Consumable Empowering High-Throughput Organ-Chip Studies
- Unlock Amorphous Solubility Enhancement For Challenging Compounds
- Quadrant 2™: Predictive Platform For Solubility And Bioavailability Enhancement
- Small Molecule Discovery Network And Capabilities
- Simplify Your Linker-Payload Synthesis
PHARMACEUTICAL AND FORMULATION DEVELOPMENT NEWS
- Amneal's Planned Sterile Facility Creates Opportunity For Aseptic Filling, Isolator, And Automation Suppliers
- Lonza Expands HPAPI Capacity In Visp, Further Supporting Its Position In Payload-Linker Manufacturing
- AustinPx Expands KinetiSol™ Technology Commercial Access Through Thermo Fisher Scientific Collaboration
- Recipharm Invests In U.S. Fill-Finish Infrastructure To Accelerate Biologics Development
- Four Myths About Embedded CMOs, Busted
- Avoiding Recalls: How To Ensure Sterility In Ophthalmic Products
- Veranova Appoints Dr. Bob Huang Vice President And General Manager Of West Deptford Site
- Leica Biosystems And CellCarta Expand Collaborative Companion Diagnostic Development Model To Accelerate Commercialization Globally
- Quotient Sciences Advances AI-Designed Drug Product Into Clinical Development
- ILC Dover Expands Life Sciences Presence With Water For Injection (WFI) And Custom Chemical Solutions