Formulation Development

Standalone instrument with touchscreen and built-in sample ports for small volumes and cuvettes

The SpectraMax® QuickDrop™ Micro-Volume Spectrophotometer quantifies very small amounts of DNA, RNA, oligos, and proteins.

An industry-renowned instrument for monitoring GPCRs and ion channels

Powered by a new, optional high-speed EMCCD camera and the new Peak Pro 2 software module, the new FLIPR® Penta High-Throughput Cellular Screening System allows you to measure and analyze peaks of human-derived induced pluripotent stem cells (hiPSCs), differentiated into cardiomyocytes and neurons, up to 100 times per second and quickly cherry pick events such as Early Afterdepolarization-like events (EAD-like events), fibrillation, and irregular beating.

Characterize the Best-Fit Structure for Your NMR and MS Data

ACD/Structure Elucidator Suite is the industry-leading software solution for computer-assisted structure elucidation (CASE). It offers a reliable workflow and accurate results for de novo elucidation of complex organic compound structures.

Use Structure Elucidator Suite to:

• Determine structures using NMR and other analytical data
• Generate all the candidate structures that fit your NMR and MS data
• Rank the generated structures and identify the most probable one
• Determine 3D configuration from a 2D structure using NOESY/ROESY data
• Dereplicate previously identified compounds
• Search fragment databases or manually define fragments for partially known structures
• Report the final structure and add SDFiles to the prediction databases

Understand Your Biotransformation Data

MetaSense helps you make sense of all your metabolite identification (MetID) data. Move beyond complex workflows that have you flipping back and forth between a dozen programs.

With a single interface for prediction, data analysis, and knowledge dashboards, make data-driven decisions swiftly.

• Collect all your MetID data and view it in one place
• Auto-generate biotransformation maps and kinetic plots
• Click between interactively linked maps and plots to see your data at any depth
• Reprocess data directly from MetaSense
• Draw conclusions about a drug candidate’s metabolism and viability

Calculators & Predictors for LogP, LogD, pK_a, Aqueous Solubility, and more…

The physicochemical properties of a molecule can help you better understand its likely behavior, support QSPR high-throughput screening (HTS) of libraries, and data-driven lead optimization.

ACD/PhysChem Suite is made up of a number of prediction modules. It provides high-quality, structure-based calculations of physicochemical properties.

• Predict aqueous solubility,^* boiling point, logD,^* logP,^* pK_a,^* Sigma, and other molecular descriptors for organic compounds, from structure
• Evaluate the calculated results with sorting, plotting tools
• Assess the reliability of predicted physicochemical property values
• Investigate quantitative structure-property relationships, structure modifications, and/or lead optimization for a target profile
• Train predictors with experimental data to better reflect novel chemical space
• Include custom models and in-house prediction algorithms

^*Models are trainable with experimental data

Leica DM300

For slightly more advanced students in biology or 2-4 year college life science classrooms, the Leica DM300 compound microscope is compact, maintenance-free and easy to use to provide trouble free operation each day.

Equipped with a mechanical stage to accommodate two specimen slides and labelled Abbe condenser, the DM300 can be configured with rotatable monocular or binocular tubes for shared viewing and easy storage. Trinocular tube is also possible to go digital.

With 165 years of microscope design and manufacturing experience, the Leica DM300 student microscope provides students with the capabilities they need to study the finest details in all the Life Sciences.

In the pharmaceutical industry, every capsule and tablet begins with a concept. Transforming that idea into a tangible product requires an expert manufacturing partner. Natoli stands out as a leader in pharmaceutical equipment and services, providing a comprehensive journey from formulation to full-scale production.

Curia’s discovery biology team accelerates your program toward the clinic and commercialization with our best-in-class, customizable solutions.