Drug Formulation, Formulation Development

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Why Early Evaluation Of Process Parameters Matters In OSD Scale-Up

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Printing A New Path To The Brain: 3D Buccal Nanofilms For CNS Lymphoma

Engineering Better ADCs, Part 2: Characterization, CMC, And More

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Engineering Better ADCs, Part 1: MoA, Conjugation Chemistry, And More

FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES

A Guide To Bioavailability Enhancement
Many new drug candidates face oral bioavailability challenges. Particle engineering, lipid systems, and inclusion complexes can boost absorption, though patient variability remains a hurdle.
A Strategic Guide For Challenging Early-Phase Molecules
Early formulation decisions for high-viscosity, unstable, and potent molecules impact scale-up, regulatory flexibility, and lifecycle value. Getting them right early helps avoid costly rework.
Advancing The Development Of Syringe-Device Combinations
Defining the design for syringe-autoinjector pairings early, through shared compatibility testing, can reduce integration risk for high-viscosity biologics intended for self-administration at home.
Nasal Delivery Of Psychedelics: Next Generation Delivery Options
Psychedelic development has moved past regulatory hurdles to a question of formulation and delivery. For fast-acting molecules, dosing control and onset speed are pushing developers toward one route.
Early Automation Integration Reshapes How Drugs Move
Introducing automation during R&D rather than in Phase 3 changes how processes scale. Unified data and standards-based control logic carry across bench, pilot, and commercial stages with less rework.

FORMULATION DEVELOPMENT APPLICATIONS & STUDIES

Long-Acting GnRH Antagonist For Advanced Prostate Cancer
Achieve rapid testosterone suppression for 6+ months with a novel low-volume subcutaneous depot formulation, eliminating the initial surge and offering a new approach for advanced prostate cancer treatment.
Why Early Device Decisions Matter: How Immunovant Accelerated Its Program
Deferring autoinjector selection can seem to preserve flexibility, yet it often moves constraints downstream. Integrating the device during Phase IIb changed one program's timeline and removed bridging work.
Using Human-Centered Engineering To Improve HPLC Solvent Handling
Real-world HPLC workflows show how closed-system solvent handling can address contamination, downtime, and waste across laboratory settings.
Reducing Cycle Time By 88% Through Strategic Solvent Replacement In Pharmaceutical Development
Replacing methylene chloride in a slow, labor-intensive API step led to a single-solvent, one-pot process with a shorter reaction time and improved yield and purity.
Improving Stability Through Science-Led OSD Reformulation
A marketed multivitamin tablet spanning a 0.03% to 46% w/w range failed early in accelerated stability testing. Mechanism-led reformulation and a switch to direct compression changed the outcome.

FORMULATION DEVELOPMENT PRODUCTS & SERVICES

GMP Manufacturing

Nanoform’s GMP facility utilizes its award-winning Controlled Expansion of Supercritical Solutions (CESS®) technology for the manufacture of API nanoparticles to GMP standards.

Uniquely Ergonomic System Microscopes With Intelligent Automation

Leica DM3000

Enhance Laboratory Workflow

The Leica DM3000 microscopes for pathology, cytology, haematology and many other applications feature a motorized nosepiece, condenser head, automated light intensity adjustment, and optional foot pedal. These intuitive microscopes improve workflows significantly. For special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) like in-vitro-fertilization (IVF).

Formulation Development

Upperton offers formulation development services to accelerate First-in-Human studies and advance projects toward clinical trials.

Imager For Live Cell & 3D Cell Culture Assays

THUNDER Imager Live Cell & 3D Assay

Decode 3D biology in real time*

With THUNDER Imagers you begin every experiment with confidence. They are your solution for advanced 3D cell culture assays, whether you want to study stem cells, spheroids, or organoids.

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Sophisticated Patch-Clamp Electrophysiology Data Acquisition And Analysis Software

Preconfigured protocols and custom assay workflows simplify microplate data acquisition and analysis

SoftMax® Pro Software for Windows 10 is designed to provide the simplicity, flexibility and power required for advanced data analysis. It provides ready-to-run protocols, analysis algorithms, and 21 different curve fit options.

Meet Your Imaging Needs With Custom Microscopy

Custom microscopy workstations to meet your advanced imaging needs.

ExionLC™ 2.0 and ExionLC™ 2.0+ Systems

Reproducibility, reliability and carryover performance that meets your workflow demands, injection to injection, batch after batch.

ExionLC 2.0 and ExionLC 2.0+ systems provide full integration, control and compatibility with SCIEX mass spectrometers bringing together the speed and precision you expect for a complete solution that meets every challenge your lab faces.

DM IL LED Inverted Laboratory Microscope

With high-performance optics and ergonomic design, the Leica DM IL LED is ideal for cell culture, micromanipulation, documentation of immunostained specimens, and routine live cell examinations.

The Leica DM IL LED features a comprehensive set of contrast methods to monitor your specimen the way you need. High-quality Phase contrast, excellent modulation contrast and brilliant fluorescence are just one fingertip away. Robust stability, plenty of space to work with tools, long working distances to accommodate large culture flasks and a stable illumination without heat make work at the microscope easy and convenient.

For special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) including in-vitro-fertilization (IVF).

Formulation Development

FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES

FORMULATION DEVELOPMENT APPLICATIONS & STUDIES

FORMULATION DEVELOPMENT PRODUCTS & SERVICES

FORMULATION DEVELOPMENT SOLUTIONS

PHARMACEUTICAL AND FORMULATION DEVELOPMENT NEWS