Formulation Development
FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES
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![pharmaceutical factory equipment-GettyImages-499694183]( "Beyond PMI: Solvents As A Key To Sustainable Process Design")
Beyond PMI: Solvents As A Key To Sustainable Process DesignDiscover how data-driven solvent selection helps uncover sustainability opportunities, boost efficiency, and enable smarter process optimization decisions.
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![Oligonucleotides-GettyImages-2234236209]( "How Data-Driven Development Is Transforming Phosphoramidites")
How Data-Driven Development Is Transforming PhosphoramiditesHigh-quality phosphoramidites are key to oligonucleotide therapies. Learn how data-driven optimization boosts purity, streamlines manufacturing, speeds scale-up, and supports commercialization.
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![pharma-partners-GettyImages-2182052451]( "Three Keys To E&L Success: Study Design, Partner Selection, And Timing")
Three Keys To E&L Success: Study Design, Partner Selection, And TimingSuccessful E&L planning starts before testing begins. Aligning study design, partner expertise, and timing helps teams focus on the right risks, avoid surprises, and support stronger development.
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![Strategies For API Solubility And Bioavailability Enhancement: Selecting Technologies And Excipients]( "Patented Process For Olopatadine HCl API Intermediates")
Patented Process For Olopatadine HCl API IntermediatesSee how this patented Wittig-based process for olopatadine HCl achieves Z/E isomer ratios up to 4:1, eliminating dangerous reagents like n-butyl lithium while cutting purification complexity.
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![Reference_image_1]( "Platform Strategy For Improving Manufacturability And Efficacy In Bispecific Antibodies")
Platform Strategy For Improving Manufacturability And Efficacy In Bispecific AntibodiesNovel bispecific antibody engineering overcomes assembly and manufacturability challenges, enabling scalable production while preserving therapeutic function, stability, purity, and product quality.
FORMULATION DEVELOPMENT APPLICATIONS & STUDIES
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![Intestinal tract with digestive health-GettyImages-1985026058]( "Predicting Food Effects In Oral Drug Delivery Using PBPK Modeling")
Predicting Food Effects In Oral Drug Delivery Using PBPK ModelingLearn how integrated PBPK and molecular dynamics modeling predicted an ~11% fed-state Cmax increase for fenofibrate, giving formulation teams earlier, mechanistic insight into food-dependent absorption.
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![GettyImages-163720603 tablet press, OSD]( "Compaction Simulation For Tablet Technology Transfer And Scale-Up")
Compaction Simulation For Tablet Technology Transfer And Scale-UpCompaction simulation de-risked tech transfer for a 40 mg fexuprazan tablet by defining optimal roller compaction and lubrication parameters before scale-up. Access the full case study to see the data.
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![GettyImages-1365580848-ubiquinol-softgel]( "Predicting Softgel Stability And Shelf Life Using Accelerated Modeling")
Predicting Softgel Stability And Shelf Life Using Accelerated ModelingPredict ibuprofen softgel shelf life in 21 days instead of years. ASAPprime modeling identified PEG-ester degradants as the limiting factor, estimating 5.5-year and 3.8-year shelf lives before long-term studies concluded.
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![White Tablets-GettyImages-172969989]( "Predicting Drug-Loading Limits In Tablet Formulations")
Predicting Drug-Loading Limits In Tablet FormulationsLearn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.
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![GettyImages-498013412-laboratory-flask-water-solubility-dropper]( "Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies")
Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement StrategiesIn silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.
FORMULATION DEVELOPMENT PRODUCTS & SERVICES
The iCELLis™ bioreactor system is an automated, single-use, fixed-bed bioreactor that provides excellent cell growth conditions for adherent cells.
Upperton have developed UpperNose™, a nasal product development approach designed to streamline the development process for nasal dosage forms.
Whether you require a particular expertise or a complete, experienced integrated small molecule discovery team, Curia can provide a high-performance solution to help turn your vision into reality.
Configurable, high-throughput widefield imaging solution for an incredible range of assays
This intuitive and reliable HPLC system supports First Time Quality (FTQ) by reducing the risk of common errors and improving the accuracy of analytical measurements.
Characterize Samples and Identify Unknown Components
Do you often need to identify unknown compounds from complex samples? ACD/MS Structure ID Suite offers a simple, replicable workflow for generating and narrowing down structural candidates.
- Deconvolute complex LC/MS and GC/MS data into individual component traces
- Search proprietary and commercial databases for spectral matches
- Search PubChem for accurate-mass and molecular-formula matches
- Narrow down candidate structures by retention time and fragment include/exclude lists
Used Elizabeth Hata R&D tablet press, model EP200, B/D tooled with 10 station turret, 5 stations each B and D, 16 mm B, 22 mm D max tablet diameter, 17 mm B, 18 mm D max depth of fill, rated up to 6000 tablets/hour, with feed hoppers and feed frames, Machine #81, built 2011.
SoftMax® Pro Software - The most published microplate reader control and data analysis software
Preconfigured protocols and custom assay workflows simplify microplate data acquisition and analysis
SoftMax® Pro Software for Windows 10 is designed to provide the simplicity, flexibility and power required for advanced data analysis. It provides ready-to-run protocols, analysis algorithms, and 21 different curve fit options. Every step is optimized for data acquired from a Molecular Devices microplate reader or data imported from another source to simplify analysis and reporting. Compliance tools are available for regulated laboratories providing end-to-end chain of custody.
FORMULATION DEVELOPMENT SOLUTIONS
- A Streamlined Approach For The APC Labeling/Conjugation Of Antibodies
- Trilysine Acetate: Enabling Advanced Surgical, Drug Delivery Tech
- Solid Form Services
- Are You In Control Of Your Protein Galactosylation Profile?
- Small Molecule Discovery Network And Capabilities
- Scaling High-Potency APIs From Consulting To Containment
- High-Quality, Cost-Effective and Reliable CDMO Solutions
- Extractables And Leachables (E&L) Control Strategy
- Largest Global Network Of Harmonized GMP Product Testing Laboratories
- Bioprocess Courses And Services
PHARMACEUTICAL AND FORMULATION DEVELOPMENT NEWS
- Amneal's Planned Sterile Facility Creates Opportunity For Aseptic Filling, Isolator, And Automation Suppliers
- Lonza Expands HPAPI Capacity In Visp, Further Supporting Its Position In Payload-Linker Manufacturing
- AustinPx Expands KinetiSol™ Technology Commercial Access Through Thermo Fisher Scientific Collaboration
- Recipharm Invests In U.S. Fill-Finish Infrastructure To Accelerate Biologics Development
- Four Myths About Embedded CMOs, Busted
- Avoiding Recalls: How To Ensure Sterility In Ophthalmic Products
- Veranova Appoints Dr. Bob Huang Vice President And General Manager Of West Deptford Site
- Leica Biosystems And CellCarta Expand Collaborative Companion Diagnostic Development Model To Accelerate Commercialization Globally
- Quotient Sciences Advances AI-Designed Drug Product Into Clinical Development
- ILC Dover Expands Life Sciences Presence With Water For Injection (WFI) And Custom Chemical Solutions