Formulation Development

Uniquely Ergonomic System Microscope Leica DM1000

The ergonomically designed Leica DM1000 with adjustable features and easy-to-use controls adapts to every user to improve comfort and convenience while working at the microscope.

Featuring high-quality optical performance, the Leica DM1000 is ideal for all clinical laboratory applications, in particular cytology, haematology, and pathology. For special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) like in-vitro-fertilization (IVF).

Its advanced capabilities, including fluorescence, make it well suited also for complex tasks.

Upperton offers formulation development services to accelerate First-in-Human studies and advance projects toward clinical trials.

Our solutions have been specified in the testing process for the top two GLP-1 manufacturers

Quality control is a critical component for ensuring safety, efficacy, and consistency in the development and production of biologics. This comprehensive list of strategies, techniques, workflows, and best-in-class products for developing biopharmaceuticals can help you navigate the complexities of biologics and simplify the manufacturing process. Improve your quality control procedures and optimize your biologics production process with tools and expertise relied upon by researchers worldwide.

Standalone instrument with touchscreen and built-in sample ports for small volumes and cuvettes

The SpectraMax® QuickDrop™ Micro-Volume Spectrophotometer quantifies very small amounts of DNA, RNA, oligos, and proteins.

Analyzing GLP-1 receptor agonist (RA) drugs has become increasingly complex. Peptide structures, closely-related impurities, and rising demands for sensitivity, speed, and compliance are putting pressure on laboratories.

Next-generation fluorescent imaging solution for the assurance of monoclonality and automated confluence across diverse cell types

Demonstrating that cell lines are monoclonal – or that a gene was edited as expected – can be a time-consuming and highly-subjective process when relying on conventional technologies. The CloneSelect® Imager and CloneSelect® Imager FL are a high-throughput automated solutions for imaging and analyzing mammalian cells. Tracking the formation of a colony from a single cell is effortless as barcoded plates are tracked over time. Automated acquisition and analysis provides accurate, objective, and consistent results.

Calculators & Predictors for LogP, LogD, pK_a, Aqueous Solubility, and more…

The physicochemical properties of a molecule can help you better understand its likely behavior, support QSPR high-throughput screening (HTS) of libraries, and data-driven lead optimization.

ACD/PhysChem Suite is made up of a number of prediction modules. It provides high-quality, structure-based calculations of physicochemical properties.

• Predict aqueous solubility,^* boiling point, logD,^* logP,^* pK_a,^* Sigma, and other molecular descriptors for organic compounds, from structure
• Evaluate the calculated results with sorting, plotting tools
• Assess the reliability of predicted physicochemical property values
• Investigate quantitative structure-property relationships, structure modifications, and/or lead optimization for a target profile
• Train predictors with experimental data to better reflect novel chemical space
• Include custom models and in-house prediction algorithms

^*Models are trainable with experimental data