ABOUT FLOW SCIENCES, INC.

Flow Sciences, Inc. (FSI) designs and manufactures containment solutions. Our commitment to safety, performance, and superior engineering quality and service is unmatched. The Flow Sciences Team is known as world leaders in containment solutions.

During the 1990s, Flow Sciences pioneered Vented Balance Safety Enclosures (VBSE™) which introduced the first independent fan exhaust system to isolate vibrations for balance accuracy. By incorporating Computational Fluid Dynamics (CFD), Flow Sciences refined the process and enlarged the enclosures, presenting product protection through framed enclosure solutions.

FEATURED PRODUCTS/SERVICES

Lateral Flow Bio Containment Isolator For HPAPI Processing: LFBC™ Lateral Flow Bio Containment Isolator For HPAPI Processing: LFBC™

Safety
The Glovebox Workstation series provides containment for highly toxic applications using APIs that need more safety than an opened face enclosure. FSI engineering controls are built in to prevent loss of containment. Third Party testing has proven containment on these units to below 30 ng/m³ based on process and quantity.

Bulk Powder Enclosure For Media And Buffer Preparation Bulk Powder Enclosure For Media And Buffer Preparation

Bulk Powder Enclosure for Media and Buffer Preparation designed to provide personnel protection while working with powder substances. The enclosure features include acrylic superstructure, black phenolic base, 20” base cutout with flange/trespa cover/SS ring, hinged door style, top mount fans, and HEPA filtration.

High Potency API Filled Capsule Inspection System High Potency API Filled Capsule Inspection System

HPAPI Capsule Inspection System is designed to provide personnel protection during the inspection of filled capsules containing Highly Potent Active Pharmaceutical Ingredient (HPAPI) powder. Accommodates space for an analytical weighing balance and capsule inspection bats (paddles). Acrylic viewing panels above enclosure face provide continuous, uninterrupted line of sight during inspection processes. Inspected product may be safely removed from the enclosure by inserting material through a continuous liner cut-out located in the center of the enclosure base. Waste is removed from the right-side continuous liner.

Tangential Flow Filtration Enclosure Tangential Flow Filtration Enclosure

Tangential Flow Filtration Enclosure designed for effective personnel and product protection while working with HPAPI powder when performing TFF (tangential flow filtration) of conjugated liquids. The enclosure features polypropylene superstructure with light-filtering acrylic panels designed to protect light-sensitive product. Additionally, the enclosure features (2x) large hinged barn doors from each side, supporting table with bottom shelf made from black phenolic, and (2x) iris ports on each side. LED lighting feature includes white and yellow color settings. Powder-coated steel table with leveling pads also included.

Quadro Comil Milling, Granulation, and Drying Enclosure Quadro Comil Milling, Granulation, and Drying Enclosure

The Quadro Comil / High Shear Diosna Milling and Granulation Enclosure designed to provide personnel protection down to a respiratory exposure concentration of 100 nanograms per cubic meter (ng/m3) during milling and granulation operations.

High Potency API Drying and Multi-Fill Suite High Potency API Drying and Multi-Fill Suite

HPAPI Drying and Multi-Fill Suite designed as a complete sampling system with a nitrogen glovebox enclosure for processing and drying of HPAPI (High Potency Active Pharmaceutical Ingredients) connected to a laminar flow hood. Designed for product and personnel protection during filling of small sampling containers.

Low Humidity Dispensing Enclosure for Solvents and Solids Low Humidity Dispensing Enclosure for Solvents and Solids

Ultra-Low Humidity Dispensing Enclosure for Solvents and Solids designed to provide product protection during solvent and solid dispensing operations which require an ultra-low humidity contained environment. Enclosure features acrylic superstructure coated with static-dissipative coating.

Agilent 218 Solvent Delivery Module Enclosure Agilent 218 Solvent Delivery Module Enclosure

Agilent 218 Solvent Delivery Module Enclosure designed to provide personnel protection while working with liquid substances. Designed to work with an Agilent 218 Solvent Delivery Module with dimensions of 19” x 12” x 8”. Enclosure features include polypropylene superstructure, black phenolic base, acrylic viewing panels, sliding doors, LED lighting, vent kit, and iris ports on both sides. LED lighting and Acrylic viewing panels maximize lighting across the workspace.

Malvern Morphologi G3 Particle Analyzer Enclosure Malvern Morphologi G3 Particle Analyzer Enclosure

Malvern Morphologi G3 Particle Analyzer Enclosure designed to provide personnel protection while working with powder substances. The enclosure features include polypropylene superstructure, flat screen swing arm mount, sliding sash door style, 3” iris ports on both sides, travel cart for Malvern Morphologi G3 with 2” iris port, digital alarm, glass panels, hinged door style, top mount fan, vent kit, thimble connection, HEPA filtration, and enclosure table. Glass panels maximize lighting across the workspace.

Pharmaceutical Freeze Dryer Cryodesiccation Suite Pharmaceutical Freeze Dryer Cryodesiccation Suite

The Lyophilizer Cryodesiccation Suite designed to provide personnel protection while working with powder substances. Designed to work with a lyophilizer with dimensions 450mm (L) x 450mm (W) x 450 mm (H) (17.72” L x 17.72” W x 17.72” H).

CleanFlow – Clean Air Workstations CleanFlow – Clean Air Workstations

The CleanFlow is a unidirectional, positive pressure, laminar air flow workstation.

Pharmaceutical Sterility Testing Isolator Pharmaceutical Sterility Testing Isolator

The Hardwall IsoSphere™-ST is a positive pressure non-unidirectional airflow isolator or unidirectional CRABS for small, medium, and large volume sterility testing with vaporized hydrogen peroxide decontamination integration.

Pharmaceutical Aseptic Filling Isolator: IsoSphere Pharmaceutical Aseptic Filling Isolator: IsoSphere

The IsoSphere-AF is a positive pressure unidirectional airflow isolator or RABS for small, medium and large volume aseptic filling.

Chemo Compounding Isolator Chemo Compounding Isolator

The ChemoSphere is a safe, clean, cost-effective C.A.C.I. for chemo compounding that is USP <797 / 800>, OSHA, AND NIOSH compliant.

Pharmaceutical Sterile Compounding Isolator: MicroSphere Pharmaceutical Sterile Compounding Isolator: MicroSphere

The MicroSphere is a clean, cost-effective C.A.I for sterile compounding, that is USP <797> compliant.

Hybrid Isolator – Dual Purpose Vented Enclosure Hybrid Isolator – Dual Purpose Vented Enclosure

Hybrid Isolator series (EHP and EHG) provides containment for highly toxic applications using APIs and HPAPIs that require personnel and/or product protection.

HPAPI Pharmaceutical Compacting And Coating Enclosure With Rolling Cart HPAPI Pharmaceutical Compacting And Coating Enclosure With Rolling Cart

Advantech Sonic Sifter Powder Weighing and Transfer Enclosure designed to provide personnel protection during compacting and coating operations involving Highly Potent Active Pharmaceutical Ingredients (HPAPI).

Highly Potent API Pharmaceutical Weighing Suite Highly Potent API Pharmaceutical Weighing Suite

Highly Potent API Weighing Suite designed to provide personnel protection down to a respiratory concentration of at least 50 nanograms per cubic meter of air (ng/m3). Design accommodates sufficient space for storage and usage of 1-2 analytical balances and/or microbalances.

Lateral Flow API Weighing and Dispensing Enclosure Lateral Flow API Weighing and Dispensing Enclosure

Lateral Flow API Weighing and Dispensing Enclosure designed to provide personnel and product protection when weighing 0.5 kilograms (kg) of API powder.

Pharmaceutical Tablet Press Enclosure Pharmaceutical Tablet Press Enclosure

Automatic Tablet Press Enclosure designed to provide personnel protection tablet pressing operations involving a Carver Press 800 ANE with dimensions 35.43” x 23.62” x 39.37 [900mm X 600mm X 1000mm]. Enclosure features a polypropylene superstructure, black phenolic base dished to contain spills, and (3x) removable sliding doors for easy loading/unloading of equipment and processed product.

Pharmaceutical Downflow Booth For Freeze Dryers / Lyophilizers Pharmaceutical Downflow Booth For Freeze Dryers / Lyophilizers

Downflow Booth for Freeze Dryer/Lyophilizer designed for product protection when conducting vial-filling and loading vialed product into a freeze-dryer. Features a 304 stainless steel alloy superstructure and perforated stainless steel base.

Vented Balance Safety Enclosure Vented Balance Safety Enclosure

For use in pharmaceutical, chemical, biological, and toxicological laboratory settings. Specifically designed to provide maximum containment for balance applications. The opening of the enclosure has uniquely designed acrylic airfoils that allow a smooth turbulence-free airflow that prevents balance fluctuation. Weigh down to 5 places without fluctuations or loss of product. The work surface is black for easy powder detection, constructed of tough, chemically resistant phenolic resin, and has a dished bottom for containing spills. Enclosures feature an ergonomic, energy efficient design with angled front for worker comfort.

API Process Development System API Process Development System

API Process Development System designed to provide personnel and product protection while working with powder and liquid substances. Designed to house a Mettler Toledo Easy Max 102, Vacuum Oven, and IKA LR 1000.

Pharmaceutical Stainless Steel Glovebox For Cytotoxic Drug Development Pharmaceutical Stainless Steel Glovebox For Cytotoxic Drug Development

Stainlees Steel Glovebox for Cytotoxic Drug Development designed to provide personnel protection while working with powder substances.

Performance Validation by Third Party Industrial Hygienists Performance Validation by Third Party Industrial Hygienists

Flow Sciences, a leading provider of containment solutions for laboratory, pilot plant, and manufacturing facilities consults with third party industrial hygienists to conduct in-house Factory Acceptance Tests (FATs) and Site Acceptance Tests (SATs) to ensure customers’ products perform at the level they need.

Laboratory Testing Services Laboratory Testing Services

Flow Sciences, Inc. (FSI) evaluates and ensures that every enclosure shipped to their customer meets all relevant standards. FSI performs procedures from the American Society of Heating, Refrigeration, and Air Conditioning Engineers (ASHRAE) 110-2016 – Methods of Testing Performance of Laboratory Fume Hoods.

HPAPI Package Inspection Enclosure HPAPI Package Inspection Enclosure

The HPAPI Package Inspection Suite is designed to provide personnel and product protection down to a respiratory exposure of at least 100 micrograms per cubic meter air (100 ug/m3). Package inspection operations involve manipulation of highly potent pharmaceutical ingredients (HPAPI), such as fentanyl. 

Mettler Toledo XS204 Powder Weighing Enclosure With ADA Rolling Cart Mettler Toledo XS204 Powder Weighing Enclosure With ADA Rolling Cart

Mettler XS204 Powder Weighing Enclosure designed to provide personnel protection when working with powdered substances down to a respiratory exposure concentration of less than 1 microgram powder per cubic meter of air (<1 ug/m3). Design accommodates sufficient space for efficient, ergonomic execution of powder weighing operations utilizing the Mettler XS204 Analytical Balance with dimensions (DxHxW) of 17.84” x 12.67” x 10.35” [453mm x 322mm x 263mm].

Integrated Glovebox And Hybrid Isolator For HPAPI Processing Integrated Glovebox And Hybrid Isolator For HPAPI Processing

Integrated Glovebox and Hybrid Isolator for HPAPI Processing designed to provide personnel protection while working with powder substances.

API Hybrid Isolator API Hybrid Isolator

API Hybrid Isolator designed to provide personnel protection while working with powder substances. Enclosure features include acrylic superstructure, black phenolic base, acrylic viewing panels, hinged door style, BIBO filtration with dual HEPA, top mount fan, vent kit, thimble connection, right and left side pass throughs, Go/No Go Red and Green Signal Light, removable draft shield with 6x 8” oval glove ports, 2x minihelic gauges, LED lighting, iris ports on both sides. LED lighting and Acrylic viewing panels maximize lighting across the workspace.

CONTACT INFORMATION

Flow Sciences Inc.

2025 Mercantile Drive

Leland, NC 28451

UNITED STATES

Phone: (910) 763-1717

Contact: Sales

FEATURED ARTICLES

  • Validation Of A Glovebox Workstation
    Validation Of A Glovebox Workstation

    Many existing research labs, pharmaceutical and biopharmaceutical manufacturers, and contract manufacturing organizations (CMO’s) are not designed nor are they equipped with the engineering controls to safely handle the manufacture of ADC’s. The safe manufacture of ADC’s requires more modern facilities, equipment, and engineering controls as well as programs, practices, and procedures to adequately protect the operators and the work environment. Read the steps that must be taken to consider a glovebox workstation fully validated to manufacture ADCs safely.

  • Critical Considerations When Selecting A Vented Balance Enclosure
    Critical Considerations When Selecting A Vented Balance Enclosure

    This paper discusses the primary benefits of the vented balance enclosure, which is critical to the safe and effective weighing of potent powder compounds, APIs, and nanomaterials. 

  • Manufacturer Finds Solution For Transporting HPAPI Product with Containment
    Manufacturer Finds Solution For Transporting HPAPI Product with Containment

    A client was in need of a containment enclosure for an analytical weighing and solution-preparation operation involving Highly Potent Active Pharmaceutical Ingredients (HPAPI) in powder form. Their goal was to transfer product from an enclosure to another enclosure. read how Flow Sciences used a recently developed containment device and augmented to fit the specific needs of the client.

  • Shipping, Assembling, And Installing Bulky Exhaust Equipment In A Lab
    Shipping, Assembling, And Installing Bulky Exhaust Equipment In A Lab

    Though delivering, unloading, staging, and assembling are required steps in all lab construction, there are design aspects of lab equipment that can contribute to its successful field installation.

  • Getting What You Need In A Laboratory Hood
    Getting What You Need In A Laboratory Hood

    Understand what information you should be communicating to the manufacturer to ensure you get the best lab containment equipment, built correctly the first time.

  • Venting Fume Hood Base Cabinets &mdash; A Better Way
    Venting Fume Hood Base Cabinets — A Better Way

    Frequently, companies have used fume hood exhaust to ventilate hood base cabinets. There is both the need for this practice and the designs for them are frequently not well thought-out. 

  • 10 Worst Containment Engineering Mistakes
    10 Worst Containment Engineering Mistakes

    Engineering is a process to develop a design to solve a problem. In the world of containment engineering, careful premeditation is important to the completion of a successful engineering project.

  • The Keys To Superior Containment In Compounding Applications
    The Keys To Superior Containment In Compounding Applications

    This paper reviews why very bad things happen when either quantity or purity of Highly Potent Active Pharmaceuticals is not properly maintained during the compounding process. Additionally, when highly potent active pharma ingredients are not effectively contained, workers may be adversely affected.

  • 10 Considerations For Balance Stability
    10 Considerations For Balance Stability

    Stability of your weighing balance is paramount when it comes to collecting reliable data for project. As the old adage goes, “Anything that can go wrong will go wrong.”. Depending on the problem, taking obvious action for a seemingly obvious solution may not result in success. The purpose of this paper is to inspire thought and dialogue regarding those “not so obvious” sources of balance stability issues. Below, you may find 10 prompt questions that will hopefully guide one in resolving those pesky head-scratchers.

  • Flow Sciences, Inc. Partners With Three Companies To Contain Lyophilization Process Of New HPAPI
    Flow Sciences, Inc. Partners With Three Companies To Contain Lyophilization Process Of New HPAPI

    On December 19, 2018; Allan W. Ader, Ph.D. (Safebridge Consultants, Inc.), and Richard Hirsh, CIH (Nektar Therapeutics) conducted a presentation along with Allan Goodman, Ph.D. of Flow Sciences, Inc. (FSI).

  • Common Fume Hood Containment Problems
    Common Fume Hood Containment Problems

    Most of us who start our careers being frustrated with this comment eventually learn that it is a cry for help from people who want effective exhaust and are focused on the most tangible element of the exhaust system, the exhaust hood.

  • Save Energy And Lab Space : Flow Sciences’ Local Exhaust Ventilation Hoods
    Save Energy And Lab Space : Flow Sciences’ Local Exhaust Ventilation Hoods

    Flow Sciences, a leading provider of containment systems for laboratory, pilot plant, and manufacturing is now shipping the LEV III™, an addition to its expanding line of standard enclosures.

BROCHURES

  • Lateral Flow Bio Containment Isolator For HPAPI Processing: LFBC™ Brochure

    The Glovebox Workstation series provides containment for highly toxic applications using APIs that need more safety than an opened face enclosure. FSI engineering controls are built in to prevent loss of containment. Third Party testing has proven containment on these units to below 30 ng/m³ based on process and quantity.

  • Flow Sciences Local Exhaust Ventilation Series

    Save energy and lab space by moving process applications out of fume hoods. Local exhaust ventilation is the most effective and efficient containment for flash chromatography, rotovaps, and more.

  • Flow Sciences Bulk Powder Containment Series

    The Bulk Powder series provides containment for large transfers of powder and pilot plant / manufacturing applications. FSI engineering controls are built in to prevent loss of containment. Third Party testing has proven containment on these units to below 1 μg/m³ based on process and quantity.

  • Flow Sciences Lab Design

    Whether you are designing a new laboratory or renovating an existing facility, it’s important to consider the fitness and applicability of fume hoods. Flow Sciences’ Saf-T-Flow™ Fume Hood Series are ducted for maximum safety and efficiency with minimum energy input.

  • Flow Sciences Compounding Pharmacy Enclosures

    The Flow Sciences vented enclosure is essential to protect your health and ensures safety by containing powder and virtually eliminating exposure to potent powders.

  • Flow Sciences Nitrogenema Series

    Containment at its driest. This enclosure is capable of protecting your process by nearly eliminating moisture or oxygen with the flow of inert gas.

  • Flow Sciences Contained Vented Enclosure Series

    The CVE series provides containment for various benchtop/scale up and nanotechnology applications.

  • Flow Sciences Hybrid Isolator Series

    With the explosion in usage of High Potency Active Pharmaceutical Ingredients (HPAPI’s), containment of these compounds and personnel protection have become of major concern to scientists. In order to combat potentially high capital outlays for equipment, many companies are looking at alternative methods of containment, including modification of existing equipment. The Hybrid Isolator, offered by Flow Sciences, Inc., is one such method of reducing the cost of containment.

  • API/HPAPI Containment Solutions For Pharmaceutical Manufacturing

    Solve your containment challenge by working with a company that understands your process, CPT, expectations, facility allowances and restrictions as well as specific equipment specifications.

More Brochures